Breaking down the COP9 Signalsome in the heart: how inactivating a protein ubiquitin ligase increases protein ubiquitylation and protects the heart.
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منابع مشابه
Breaking Down the COP9 Signalsome in the Heart: How Inactivating a Protein Ubiquitin Ligase Increases Protein Ubiquitylation and Protects the Hear
Cellular function depends on protein homeostasis, also known as proteostasis1. Proteostasis requires the efficient folding of nascent proteins, as well as the maintenance of mature protein folding. Overseeing proteostasis is a quality control process involving the surveillance of protein-folding status, i.e. protein quality analysis, and the subsequent degradation of proteins that do not pass q...
متن کاملCOP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.
RATIONALE Impaired degradation of misfolded proteins is associated with a large subset of heart diseases. Misfolded proteins are degraded primarily by the ubiquitin-proteasome system, but the ubiquitin ligases responsible for the degradation remain largely unidentified. The cullin deneddylation activity of the COP9 signalosome (CSN) requires all 8 CSN subunits (CSN1 through CSN8) and regulates ...
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Objective(s):Small ubiquitin-like modifiers (SUMOs) are a family of ubiquitin-related, proteins that are involved in a wide variety of signaling pathways. SUMOylation, as a vital post translational modification, regulate protein function in manycellular processes. Diazinon (DZN), an organophosphate insecticide, causses oxidative stress and subsequently programmed cell death in different tissues...
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متن کاملMuscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.
Muscle-specific RING finger protein 1 (MuRF1) is a sarcomere-associated protein that is restricted to cardiac and skeletal muscle. In skeletal muscle, MuRF1 is up-regulated by conditions that provoke atrophy, but its function in the heart is not known. The presence of a RING finger in MuRF1 raises the possibility that it is a component of the ubiquitin-proteasome system of protein degradation. ...
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عنوان ژورنال:
- Circulation research
دوره 117 11 شماره
صفحات -
تاریخ انتشار 2015